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L0668

Anti-LAMP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CD107B, Anti-LGP110, Anti-Lysosomal Membrane Glycoprotein-type B (LGP-B), Anti-Lysosome-Associated Membrane Protein 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01864612
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB CL
Citations:
37
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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~110 kDa

species reactivity

human (predicted), mouse, rat

technique(s)

indirect immunofluorescence: 10-20 μg/mL using rat NRK and mouse NIH3T3 cells, western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells

UniProt accession no.

P13473

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LAMP2(3920)
mouse ... Lamp2(16784)
rat ... Lamp2(24944)

General description

LAMP2 (lysosome-associated membrane protein 2) is a heavily glycosylated intrinsic protein (110kD) present in lysosomal membrane. The protein glycosylation is essential for its function to protect the lysosomal membrane from proteolytic enzymes. Anti-LAMP2 antibody can be used in western blotting. It can also be used as a lysosomal marker. Rabbit anti-LAMP2 antibody reacts specifically with LAMP2 of mouse and rat.
LAMP2 encodes a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome.
Lysosomal associated membrane protein 2 (LAMP2) gene is located on human chromosome Xq24. LAMP2 is majorly expressed in lysosomes. It has three isoforms, that is LAMP2A, LAMP2B and LAMP2C.

Immunogen

synthetic peptide corresponding to amino acid residues 404-415 of mouse LAMP2 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in rat and differs by two amino acids in human.

Application

Anti-LAMP2 antibody can be used in immunofluorescence and immunoblotting
Anti-LAMP2 antibody produced in rabbit has been used in immunohistochemical analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Lysosomal associated membrane protein 2 (LAMP2) promotes cell-cell adhesion. It maintains cellular homeostasis and stress.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

低风险生物材料
常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
016M4840V
024M4856V
082M4765V
031M4756
060M4774

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Related Content

Suraj Dixit et al.
Molecular pharmaceutics, 12(9), 3250-3260 (2015-07-23)
Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epidermal growth
Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively.
Mattei MG, et al.
The Journal of Biological Chemistry, 265(13), 7548-7551 (1990)
Olga A Mareninova et al.
Cellular and molecular gastroenterology and hepatology, 1(6), 678-694 (2015-12-23)
The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, we investigate the role of lysosome associated membrane proteins (LAMPs) in pancreatitis.
View All Related Papers

Global Trade Item Number

SKUGTIN
L0668-200UL04061838105981