L2407
Luzindole
≥90%, melatonin receptor antagonist
Synonym(s):
N-Acetyl-2-benzyltryptamine, N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide
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About This Item
Empirical Formula (Hill Notation):
C19H20N2O
CAS Number:
Molecular Weight:
292.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥90%
Quality level:
Product Name
Luzindole, ≥90%
Quality Level
assay
≥90%
solubility
DMSO: 5 mg/mL
storage temp.
−20°C
SMILES string
CC(=O)NCCc1c(Cc2ccccc2)[nH]c3ccccc13
InChI
1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
InChI key
WVVXBPKOIZGVNS-UHFFFAOYSA-N
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
Application
Luzindole has been used as a MT1/MT2 receptor antagonist to detect the role of the melatonin receptor in neutrophil migration
Biochem/physiol Actions
Luzindole is a melatonin (mel) receptor antagonist. It has higher affinity towards the Mel 1b receptor than the Mel 1a receptor subtype.
Features and Benefits
This compound is featured on the Melatonin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Rafael Ochoa-Sanchez et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 318-325 (2012-07-14)
Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein-coupled receptors, denoted MT(1) and MT(2). However, the particular role of
Alicia González et al.
Journal of pineal research, 52(1), 12-20 (2011-07-02)
Melatonin inhibits the genesis and growth of breast cancer by interfering at different levels in the estrogen-signaling pathways. Melatonin inhibits aromatase activity and expression in human breast cancer cells, thus behaving as a selective estrogen enzyme modulator. As the adipose
Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation
Ren DL, et al.
The Journal of Endocrinology, 227(1), 49-60 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L2407-5MG | 04061833950050 |