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M0880

Ethyl methanesulfonate

liquid

Synonym(s):

Ethyl mesylate, Methanesulfonic acid ethyl ester

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About This Item

Linear Formula:
CH3SO3CH2CH3
CAS Number:
62-50-0
Molecular Weight:
124.16
UNSPSC Code:
12352108
NACRES:
NA.25
PubChem Substance ID:
24896575
EC Number:
200-536-7
Beilstein/REAXYS Number:
773969
MDL number:
MFCD00007559
Form:
liquid
Quality level:
200
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form

liquid

Quality Level

200

refractive index

n20/D 1.418 (lit.)

bp

85-86 °C/10 mmHg (lit.)

density

1.206 g/mL at 20 °C

SMILES string

CCOS(C)(=O)=O

InChI

1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3

InChI key

PLUBXMRUUVWRLT-UHFFFAOYSA-N

Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

212.0 °F

flash_point_c

100 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1105
BCCF0900
BCCD0159
BCBZ8402
BCBW8635

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Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Novel wine yeast with ARO4 and TYR1 mutations that overproduce `floral?aroma compounds 2-phenylethanol and 2-phenylethyl acetate
Cordente AG, et al.
Applied Microbiology and Biotechnology, 1-12 (2018)
Scanning ethyl methanesulphonate effects on the whole genome of Lotus japonicus using second generation sequencing analysis
Mohd-Yusoff NF, et al.
G3 (Bethesda, Md.), g3-114 (2015)
Establishment of a human somatic hybrid cell line for recombinant protein production
Cho MS, et al.
Journal of Biomedical Science, 9(6), 631-638 (2002)
View All Related Papers

Global Trade Item Number

SKUGTIN
M0880-10G04061837841064
M0880-100G04061837841057
M0880-1G04061834037521
M0880-25G04061834037538
M0880-5G04061837841071