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M1318

Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride, F 2207, Midalcipran, Toledomin

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₂N₂O · HCl

CAS Number:

101152-94-7

Molecular Weight:

282.81

NACRES:

NA.77

PubChem Substance ID:

329817868

UNSPSC Code:

12352200

MDL number:

MFCD00901293

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

description

Relative stereochemistry, Store with desiccants

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: 19 mg/mL

originator

Cypress Bioscience

storage temp.

2-8°C

SMILES string

Cl[H].CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

InChI

1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

InChI key

XNCDYJFPRPDERF-PBCQUBLHSA-N

Description

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

Features and Benefits

This compound was developed by Cypress Bioscience. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

P Okkerse et al.

European journal of pain (London, England), 21(3), 494-506 (2016-09-22)

Serotonin-norepinephrine reuptake inhibitors inhibit the reuptake of serotonin and noradrenalin and are used in the treatment of neuropathic pain. Animal studies suggest that milnacipran co-administered with opioids may potentiate the analgesic effect of μ-opioid receptor agonists. This study hypothesized that

Inhibitory Effects of Antidepressants on Acetylcholine-Induced Contractions in Isolated Guinea Pig Urinary Bladder Smooth Muscle.

Junji Uno et al.

Pharmacology, 99(1-2), 89-98 (2016-10-25)

To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. Concentration-response curves for ACh-induced contractions in guinea

Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug.

C Moret et al.

Neuropharmacology, 24(12), 1211-1219 (1985-12-01)

The present study of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane(Z) hydrochloride, was undertaken to determine its biochemical profile. The properties of midalcipran, in inhibiting the uptake of monoamines were tested and compared with that of imipramine. In vitro, midalcipran was found to

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Global Trade Item Number

SKU	GTIN
M1318-10MG	04061834038139
M1318-50MG	04061832082844