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M149

Methiothepin mesylate salt

Name: Methiothepin mesylate salt
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt

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About This Item

Linear Formula:

C₂₀H₂₄N₂S₂ · CH₃SO₃H

CAS Number:

74611-28-2

Molecular Weight:

452.65

NACRES:

NA.77

PubChem Substance ID:

24278104

UNSPSC Code:

12352200

MDL number:

MFCD00153831

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: 13 mg/mL

SMILES string

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChI key

CZMDZGZYKOGLJY-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)

Description

General description

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

Application

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

Biochem/physiol Actions

Methiothepin mesylate salt is a 5-HT₁, 5-HT₆, 5-HT₇ serotonin receptor antagonist, which blocks serotonin autoreceptors.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Functional, endogenously expressed 5-hydroxytryptamine 5-ht7 receptors in human vascular smooth muscle cells.

P Schoeffter et al.

British journal of pharmacology, 117(6), 993-994 (1996-03-01)

Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50

Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.

C Grånäs et al.

European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)

Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies

Primary neuronal precursors in adult crayfish brain: replenishment from a non-neuronal source

Benton J L, et al.

BMC Neuroscience, 12(1), 53-53 (2011)

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Global Trade Item Number

SKU	GTIN
MABN1773	04055977181630
M149-100MG	04061834040682
M149-250MG	04061834040699