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M2518

Menadione sodium bisulfite

BioReagent, suitable for cell culture, ≥95% (TLC)

Synonym(s):

2-Methyl-1,4-naphthoquinone sodium bisulfite

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About This Item

Empirical Formula (Hill Notation):
C11H9NaO5S
CAS Number:
130-37-0
Molecular Weight:
276.24
NACRES:
NA.75
PubChem Substance ID:
24896741
UNSPSC Code:
12352205
EC Number:
204-987-0
MDL number:
MFCD00051456
Assay:
≥95% (TLC)
Form:
powder
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biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

assay

≥95% (TLC)

form

powder

mol wt

Mw 276.24 g/mol

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

solubility

water: soluble 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

[Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O

InChI

1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1

InChI key

XDPFHGWVCTXHDX-UHFFFAOYSA-M

Application

Menadione sodium bisulfite has been used:
  • as a free radical inducer to study its effects on oxidative stress in sunflower seedlings
  • as a positive control to produce mitochondrial O2 during the measurement of O2 in human proximal tubular cell lines
  • as a redox-cycling mitochondrial pro-oxidant to study its effects on protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling in cardiac cells

Biochem/physiol Actions

Menadione sodium bisulfite (MSB) is a derivative of vitamin K3 and has been studied in the treatment of hemorrhagic diseases like hypoprothrombinemia and neonatal hemorrhage, caused due to vitamin K3 deficiency. It is also considered a nutritional supplement for animals. MSB shows anticancer effects. It also protects plants from biotic and abiotic stress.

Other Notes

Water soluble vitamin K3.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

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pictograms

Exclamation markEnvironment
GHS07,GHS09

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Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD1597V
SLCF3246
SLCB4832
SLBZ3230
SLBS1584V

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Y Sanada et al.
Free radical research, 48(8), 919-928 (2014-05-29)
Human oxidation resistance 1 (OXR1) functions in protection against oxidative damage and its homologs are highly conserved in eukaryotes examined so far, but its function still remains uncertain. In this study, we identified a homolog (LMD-3) of human OXR1 in
Kenneth W Olsen et al.
Molecular vision, 17, 270-278 (2011-02-02)
The crystalline lens is a unique cellular organ that performs metabolic processes while maintaining transparency for optical functionality. Mitochondria play a role in providing cells with aerobic respiration necessary for these metabolic processes. Using menadione, a mitochondria-specific inhibitor of the
Dmytro V Gospodaryov et al.
Biochimica et biophysica acta, 1837(11), 1861-1869 (2014-08-16)
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased
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Global Trade Item Number

SKUGTIN
M2518-100G04061835568819