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M4910

1-Methylhistamine dihydrochloride

Name: 1-Methylhistamine dihydrochloride
Brand: SIGMA

≥98% (TLC), powder

Synonym(s):

1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₁N₃ · 2HCl

CAS Number:

6481-48-7

Molecular Weight:

198.09

UNSPSC Code:

12352204

PubChem Substance ID:

24277805

NACRES:

NA.32

MDL number:

MFCD00037000

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Properties

Product Name

1-Methylhistamine dihydrochloride, ≥98% (TLC), powder

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].Cn1cnc(CCN)c1

InChI

1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H

InChI key

AGXVEALMQHTMSW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)

Description

Application

1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.

Biochem/physiol Actions

1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.

Major metabolite of histamine by histamine N-methyltransferase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease.

Mouhammad Motawaj et al.

Journal of Alzheimer's disease : JAD, 22(3), 861-871 (2010-09-23)

Neuropathological studies have reported a strong neurofibrillary degeneration of the tuberomamillary nucleus, the region of origin of histamine neurons, in Alzheimer's disease (AD). Histaminergic neurons enhance cognition and memory, suggesting that their degeneration may contribute to the cognitive decline of

Glucagon-like peptide-1, corticotropin-releasing hormone, and hypothalamic neuronal histamine interact in the leptin-signaling pathway to regulate feeding behavior.

Koro Gotoh et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(9), 1131-1133 (2005-05-17)

Glucagon-like peptide-1 (GLP-1), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine suppress food intake, a target of leptin action in the brain. This study examined the interactions of GLP-1, CRH, and histamine downstream from the leptin-signaling pathway in regulating feeding behavior.

Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.

F Gbahou et al.

The Journal of pharmacology and experimental therapeutics, 334(3), 945-954 (2010-06-10)

We previously suggested that therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). However, H(3)Rs exhibit constitutive activity, and most H(3)R antagonists act as inverse agonists. Here, we have investigated the effects

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Global Trade Item Number

SKU	GTIN
M4910-100MG	04061833272886
M4910-25MG	04061834059318