M5693
MEDICA 16
powder, ≥97% (HPLC)
Synonym(s):
3,3,14,14-Tetramethylhexadecanedioic acid
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About This Item
Empirical Formula (Hill Notation):
C20H38O4
CAS Number:
Molecular Weight:
342.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
assay
≥97% (HPLC)
form
powder
color
white to beige
mp
154-159 °C
solubility
DMSO: 10 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
SMILES string
CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O
InChI
1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
InChI key
HYSMCRNFENOHJH-UHFFFAOYSA-N
Biochem/physiol Actions
MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent.
MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent. The product is hypolipidemic, antidiabetic, and shows reduced adiposity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Articles
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
Bella Kalderon et al.
American journal of physiology. Endocrinology and metabolism, 284(4), E795-E803 (2002-12-19)
The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The
G Rose-Kahn et al.
Biochimica et biophysica acta, 1042(2), 259-264 (1990-02-06)
Rat liver acetyl-CoA carboxylase activity was inhibited by the free as well as the CoA monothioester of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) (Bar-Tana, J., Rose-Kahn, G. and Srebnik, M. (1985) J. Biol. Chem. 260, 8404-8410 (1985). (1) The CoA
O Hermesh et al.
Biochimica et biophysica acta, 1457(3), 166-174 (2000-04-25)
Calcium-dependent uncoupling of liver mitochondrial oxidative phosphorylation by a non-metabolizable long chain fatty acyl analogue was compared with uncoupling induced by in vivo thyroid hormone treatment. beta,beta'-Methyl-substituted hexadecane alpha, omega-dioic acid (Medica 16) is reported here to induce a saturable
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M5693-5MG | 04061833057919 |