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M7279

N,N′-Methylenebisacrylamide

Name: <I>N</I>,<I>N</I>′-Methylenebisacrylamide
Brand: SIGMA

powder, Molecular Biology, suitable for electrophoresis, ≥99.5%

Synonym(s):

BIS

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About This Item

Linear Formula:

(CH₂=CHCONH)₂CH₂

CAS Number:

110-26-9

Molecular Weight:

154.17

UNSPSC Code:

41105319

NACRES:

NB.22

PubChem Substance ID:

24897151

EC Number:

203-750-9

Beilstein/REAXYS Number:

1706297

MDL number:

MFCD00008625

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Properties

grade

Molecular Biology

Quality Level

200

assay

≥99.5%

form

powder

technique(s)

electrophoresis: suitable

impurities

≤0.05% Free carboxylic acid (T), ≤50 mg/kg Total sulfur (as SO₄) (ICP)

conductivity

≤10 μmho (2% solution)

anion traces

chloride (Cl^-): ≤50 mg/kg

cation traces

Ca: ≤10 ppm, Cd: ≤5 ppm, Co: ≤5 ppm, Cr: ≤5 ppm, Cu: ≤5 ppm, Fe: ≤5 ppm, K: ≤50 ppm, Mg: ≤5 ppm, Mn: ≤5 ppm, Na: ≤50 ppm, Ni: ≤5 ppm, Pb: ≤5 ppm, Zn: ≤5 ppm

absorption

≤0.2 at 290 at 1%

foreign activity

DNase and RNase, none detected

SMILES string

C=CC(=O)NCNC(=O)C=C

InChI

1S/C7H10N2O2/c1-3-6(10)8-5-9-7(11)4-2/h3-4H,1-2,5H2,(H,8,10)(H,9,11)

InChI key

ZIUHHBKFKCYYJD-UHFFFAOYSA-N

Description

General description

N,N′-Methylenebisacrylamide is commonly called as bis. It is used as a cross-linking agent in the preparation of polyacrylamide gels consisting of chains of acrylamide monomers. The concentration of N,N′-methylenebisacrylamide and acrylamide determines the pore size of the gel. The higher concentration of bis forms rigid gels with smaller pores due to more cross-linking leading to polymerization and vice versa.

Application

N,N′-Methylenebisacrylamide has been used:

as a crosslinker in the monomer solution to prepare N,N-dimethyl acrylamide (DMAAm)-based cryogel and acrylamide (AAm)-based cryogel matrix
as a crosslinker to prepare tough hydrogel network
in the preparation of acrylamide-bisacrylamide stock solution for the preparation of polyacrylamide gel

To be mixed with acrylamide for making polyacrylamide gels for use in protein and nucleic acid electrophoresis.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H312,H340,H350,H361fd,H372

pcodes

P202 - P260 - P264 - P280 - P301 + P310 - P302 + P352 + P312

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 1B - Muta. 1B - Repr. 2 - STOT RE 1 Oral

target_organs

Peripheral nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Ultrastretchable Conductor Fabricated on Skin-Like Hydrogel-Elastomer Hybrid Substrates for Skin Electronics

Kim SH, et al.

Advanced Materials, 30(26), 1800109-1800109 (2018)

Fundamentals and Techniques of Biophysics and Molecular Biology (2018)

Depletion of hemoglobin and carbonic anhydrase from erythrocyte cytosolic samples by preparative clear native electrophoresis

Damici GM, et al.

Nature Protocols, 7(1), 36-36 (2012)

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Global Trade Item Number

SKU	GTIN
M7279-100G	04061835546893
M7279-250G	04061835546909
M7279-25G	04061835522408