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M7891

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Name: <I>N</I>-Methyl-<I>N</I>-(trimethylsilyl)trifluoroacetamide
Brand: SIGMA

BioReagent, for silylations, LiChropur^™

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:

CF₃CON(CH₃)Si(CH₃)₃

CAS Number:

24589-78-4

Molecular Weight:

199.25

UNSPSC Code:

12352111

NACRES:

NA.25

PubChem Substance ID:

57654411

EC Number:

246-331-6

Beilstein/REAXYS Number:

1941550

MDL number:

MFCD00000411

Form:

liquid

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Properties

vapor density

>1 (vs air)

Quality Level

100

vapor pressure

8.8 mmHg ( 27 °C)

product line

BioReagent

form

liquid

quality

for silylations, LiChropur^™

reaction suitability

reaction type: Silylations, reagent type: derivatization reagent

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

solubility

chloroform: soluble 0.1 mg/mL

density

1.07 g/mL at 25 °C (lit.), 1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

Description

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide(MSTFA) is a BioReagent commonly used for silylation reactions in analyticalchemistry.

Application

N-Methyl-N-(trimethylsilyl)trifluoroacetamide can be used:

In the derivatization step of the metabolomics analysis using gas chromatography/mass spectrometry (GC/MS).
Derivatization reagent in gas chromatography with flame ionization detection (GC-FID) analysis.

Packaging

Sealed ampules contain 1 ml. Gram sizes are in screw-cap bottles.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS02,GHS07

signalword

Warning

hcodes

H226,H315,H319,H335

pcodes

P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

77.0 °F - closed cup

flash_point_c

25 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Determination of drugs of abuse in water by solid-phase extraction, derivatisation and gas chromatography-ion trap-tandem mass spectrometry.

Iria González-Mariño et al.

Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)

An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives

Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites.

Stina K Lien et al.

Journal of chromatography. A, 1247, 118-124 (2012-06-15)

GC-MS analysis of silylated metabolites is a sensitive method that covers important metabolite groups such as sugars, amino acids and non-amino organic acids, and it has become one of the most important analytical methods for exploring the metabolome. Absolute quantitative

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Global Trade Item Number

SKU	GTIN
M7891-10X1ML	04061838258540
M7891-1ML	04061834062448
M7891-10AMP	04061837684937
M7891-1AMP	04061837684944
M7891-1ML-KC	04061838088161
M7891-25G	04061837684951
M7891-5G	04061837684968