M9429
Menadione
meets USP testing specifications
Synonym(s):
2-Methyl-1,4-naphthoquinone, Vitamin K3
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About This Item
Empirical Formula (Hill Notation):
C11H8O2
CAS Number:
Molecular Weight:
172.18
UNSPSC Code:
12352205
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-372-6
Beilstein/REAXYS Number:
1908453
MDL number:
biological source
synthetic (organic)
Quality Level
agency
USP/NF, meets USP testing specifications
assay
98.5-101.0% dry basis
form
solid
mp
105-107 °C (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
CC1=CC(=O)c2ccccc2C1=O
InChI
1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI key
MJVAVZPDRWSRRC-UHFFFAOYSA-N
Gene Information
human ... NQO1(1728)
General description
Menadione (Vitamin K3) is the synthetic form of vitamin K. It has the structure similar to vitamin K1 and K2. Vitamin K1, K2 and K3 are biologically active. Water soluble forms of menadiones are used in swine and poultry diets.
Application
Menadione has been used:
- to treat HL-60 cells as positive control for apoptosis for flow cytometry
- as an oxidative stress inducer in transgenic embryos after 24 h of post fertilization
- to treat HaCaT cell line, for quantifying total and oxidised glutathione
Biochem/physiol Actions
Menadione is an oxidative stress inducer.
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Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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The Transgenic Zebrafish Display Fluorescence Reflecting the Expressional Dynamics of Dihydrofolate Reductase
Chang WN, et al.
Zebrafish, 14(3), 223-235 (2017)
Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Bauman BM, et al.
Free Radical Biology & Medicine, 124(3), 532-540 (2018)
Nutrient Requirements of Swine, 75-75 (1998)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M9429-100G | 04061833622773 |
| M9429-25G | 04061834064312 |