M9948
Mirin
≥98% (HPLC), Mre11–Rad50–Nbs1 complex inhibitor, powder
Synonym(s):
5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
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About This Item
Empirical Formula (Hill Notation):
C10H8N2O2S
CAS Number:
Molecular Weight:
220.25
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Mirin, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
red to orange
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
InChI
1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
InChI key
YBHQCJILTOVLHD-YVMONPNESA-N
Gene Information
human ... MRE11A(4361)
Application
Mirin has been used:
- as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
- as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
- in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)
Biochem/physiol Actions
Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.
Mirin is an inhibitor of the Mre11–Rad50–Nbs1 complex.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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J-Y Wang et al.
Oncogene, 35(13), 1657-1670 (2015-06-23)
DNA repair is critical for the maintenance of genome stability. Upon genotoxic stress, dysregulated DNA repair may induce apoptosis. Translin-associated factor X (TRAX), which was initially identified as a binding partner of Translin, has been implicated in genome stability. However
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Piscitello D, et al.
Oncogene, 37(4), 427-427 (2018)
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Edwards TG and Fisher C
Antiviral Research, 152(4), 68-75 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M9948-25MG | 04061832722931 |
| M9948-5MG | 04061834064688 |