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N0761

Nicotinic acid

Name: Nicotinic acid
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Synonym(s):

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃

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About This Item

Empirical Formula (Hill Notation):

C₆H₅NO₂

CAS Number:

59-67-6

Molecular Weight:

123.11

UNSPSC Code:

12352207

NACRES:

NA.71

PubChem Substance ID:

24897443

EC Number:

200-441-0

Beilstein/REAXYS Number:

109591

MDL number:

MFCD00006391

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Properties

product line

BioReagent

Quality Level

200

assay

≥98%

form

powder

mol wt

M_w 123.11 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

pH

3.4 (20 °C, 10 g/L)

mp

236-239 °C (lit.)

solubility

1 M NaOH: soluble 50 mg/mL, clear, colorless to very faintly yellow

density

1.473 g/cm³ at 25 °C

application(s)

agriculture

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

Description

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pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect.

Beat Müller et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 20(2), 181-195 (2003-10-11)

A novel methodology for establishing a pharmacological dose-effect relationship of methyl nicotinate, hexyl nicotinate and nicotinic acid acting as peripheral vasodilators in the skin following topical application is investigated. This methodology involves the estimation of the unbound drug concentration in

The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.

Paul M Lavigne et al.

Journal of the American College of Cardiology, 61(4), 440-446 (2012-12-26)

This study sought to assess the efficacy of niacin for reducing cardiovascular disease (CVD) events, as indicated by the aggregate body of clinical trial evidence including data from the recently published AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High

Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.

Koon K Teo et al.

Stroke, 44(10), 2688-2693 (2013-07-25)

In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental

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Global Trade Item Number

SKU	GTIN
N0761-100G	04061834093060