N144
Nitrendipine
>95%, powder
Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
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About This Item
Empirical Formula (Hill Notation):
C18H20N2O6
CAS Number:
Molecular Weight:
360.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
254-513-1
MDL number:
Quality Level
assay
>95%
form
powder
color
yellow to green
solubility
methanol: 15 mg/mL, DMSO: 17.5 mg/mL, H2O: insoluble
SMILES string
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC
InChI
1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChI key
PVHUJELLJLJGLN-UHFFFAOYSA-N
Gene Information
human ... ADORA3(140), CACNG1(786), KCNH1(3756), TTR(7276)
rat ... Adora1(29290), Adora2a(25369)
Biochem/physiol Actions
Ca2+ channel blocker; anti-hypertensive.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Dengning Xia et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 446-454 (2012-04-10)
The amorphous-to-crystalline transformation of nitrendipine was investigated using Raman spectroscopy and X-ray powder diffraction (XRPD). The nucleation and growth rate of crystalline nitrendipine in a medium containing poly (vinyl alcohol) (PVA) and polyethylene glycol (PEG 200) were quantitatively determined using
Dewei Shang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3459-3464 (2011-10-05)
A HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 μL) were injected directly onto a CAPCELL MF C(8)
Peng Quan et al.
International journal of pharmaceutics, 430(1-2), 366-371 (2012-04-26)
In this study, chitosan, a cationic polymer with positive charge, was introduced to modify the nanocrystals of nitrendipine with negative charge. The nanocrystals were prepared via precipitation-high pressure homogenization method. Then the nanocrystals were dispersed into chitosan solution, and the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N144-100MG | 04061832962214 |
| N144-25MG | 04061832962221 |
| N144-500MG | 04061832962238 |