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N2126

Neostigmine methyl sulfate

Name: Neostigmine methyl sulfate
Brand: SIGMA

Synonym(s):

3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium methyl sulfate

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₂₂N₂O₆S

CAS Number:

51-60-5

Molecular Weight:

334.39

NACRES:

NA.77

PubChem Substance ID:

24897553

UNSPSC Code:

12352200

EC Number:

200-109-5

MDL number:

MFCD00011796

Form:

solid

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Properties

form

solid

storage temp.

−20°C

SMILES string

COS([O-])(=O)=O.CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

InChI

1S/C12H19N2O2.CH4O4S/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;1-5-6(2,3)4/h6-9H,1-5H3;1H3,(H,2,3,4)/q+1;/p-1

InChI key

OSZNNLWOYWAHSS-UHFFFAOYSA-M

Gene Information

human ... ACHE(43)

Description

Biochem/physiol Actions

Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.

Reversible inhibitor of acetylcholinesterase; does not cross the blood-brain barrier.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H315,H319,H334,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.

C T Sadashiva et al.

Bioorganic & medicinal chemistry letters, 16(15), 3932-3936 (2006-06-01)

The cholinergic hypothesis of Alzheimer's disease (AD) has spurred the development of numerous structural classes of compounds with different pharmacological profile aimed at increasing central cholinergic neurotransmission. Thus proving a symptomatic treatment for this disease are cholinomimetics with the pharmacological

Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.

Qian-Sheng Yu et al.

Bioorganic & medicinal chemistry, 18(13), 4687-4693 (2010-07-16)

The N-monophenylcarbamate analogues of neostigmine methyl sulfate (6) and pyridostigmine bromide (8) together with their precursors (5), (7), and the N(1)-methylammonium analogues of (-)-phenserine (12), (-)-tolserine (14), (-)-cymserine (16) and (-)-phenethylcymserine (18) were synthesized to produce long-acting peripheral inhibitors of

The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system.

Oyun Khookhor et al.

Neuro endocrinology letters, 34(1), 58-61 (2013-03-26)

We previously demonstrated that the direct microinjection of cholinesterase inhibitor (neostigmine) into the hippocampus in rats activated the hypothalamo-pituitary -adrenal axis and increased the level of norepinephrine in the plasma. In the current study we tried to measure the effects

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Global Trade Item Number

SKU	GTIN
N2126-500MG	04061834110125
N2126-1G	04061835557950
N2126-5G	04061834110132