N216
Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse
clone C2C12
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About This Item
Conjugate:
unconjugated
Clone:
C2C12, monoclonal
Application:
IHC (f), IP, WB
Citations:
16
biological source
mouse
Quality Level
conjugate
unconjugated
antibody product type
primary antibodies
clone
C2C12, monoclonal
form
liquid
mol wt
antigen 120 kDa (mature exchanger), antigen 160 kDa (non-reduced), antigen 70 kDa (proteolytic fragment)
species reactivity
human, rat, canine, rabbit, guinea pig
technique(s)
immunohistochemistry (frozen sections): 1:200, immunoprecipitation (IP): suitable, western blot: 1:1,000
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC8A1(6546)
General description
Na+/Ca2+ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.
Immunogen
dog cardiac Na+/Ca2+ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane.
Biochem/physiol Actions
Na+/Ca2+ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca2+ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na+ or Ca2+.
The antibody reacts specifically with Na+/Ca2+ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues.
Physical form
Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
常规特殊物品
低风险生物材料
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Related Content
Instructions
Ping-Chun Li et al.
PloS one, 9(2), e85909-e85909 (2014-02-06)
Levosimendan, a known calcium sensitizer with positive inotropic and vasodilating properties, might also be cardioprotective during ischemia-reperfusion (I/R) insult. Its effects on calcium homeostasis and apoptosis in I/R injury remain unclear. Na(+)/Ca(2+) exchanger (NCX) is a critical mediator of calcium
Wakam Chang et al.
Nucleus (Austin, Tex.), 6(1), 77-88 (2015-01-15)
Myoblast migration is essential for muscle development and repair; however, the factors that contribute to the polarity of migrating myoblasts are relatively unknown. We find that randomly migrating C2C12 myoblasts orient their centrosomes in the direction of migration. Using wounded
Florian Steinberg et al.
The Journal of biological chemistry, 285(3), 2193-2202 (2009-11-19)
FGFRL1 (fibroblast growth factor receptor like 1) is the fifth and most recently discovered member of the fibroblast growth factor receptor (FGFR) family. With up to 50% amino acid similarity, its extracellular domain closely resembles that of the four conventional
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N216-100UL | 04061838164230 |