N3136
Naltrexone hydrochloride
≥99% (HPLC), powder, opioid receptor antagonist
Synonym(s):
Naltrexone HCl
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About This Item
Empirical Formula (Hill Notation):
C20H23NO4 · HCl
CAS Number:
Molecular Weight:
377.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
240-723-0
MDL number:
Beilstein/REAXYS Number:
3580333
Form:
powder
Quality level:
Product Name
Naltrexone hydrochloride,
form
powder
Quality Level
originator
Novartis
storage temp.
2-8°C
SMILES string
Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
InChI
1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
InChI key
RHBRMCOKKKZVRY-ITLPAZOVSA-N
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
Application
Naltrexone hydrochloride has been used:
- as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
- to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
- in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
涉药品监管产品
涉药品监管产品
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Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders
Katner SN, et al.
Behavioural Brain Research, 365, 7-16 (2019)
P Bienkowski et al.
European journal of pharmacology, 374(3), 321-327 (1999-07-28)
It has been repeatedly reported that endogenous opioid pathways play an important role in ethanol drinking behaviour. In line with these findings, a non-selective opioid receptor antagonist, naltrexone, seems to reduce relapse rates in detoxified alcoholics. The aim of the
Raquel Moreno-Vicente et al.
Journal of pharmaceutical and biomedical analysis, 114, 105-112 (2015-06-04)
A bioanalytical method using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for simultaneous quantification of heroin, its main metabolites and naloxone. In addition, naltrexone was detected qualitatively. This method was used to analyse human plasma samples from
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N3136-250MG | 04061832557502 |
| N3136-100MG | 04061834115809 |
| N3136-1G | 04061826203408 |