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Merck
CN

N3279

Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse

clone 25623, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-NGF-β

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
25623, monoclonal
Application:
ELISA (c), Neutral
Citations:
10
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

25623, monoclonal

form

lyophilized powder

species reactivity

human, rat, mouse

technique(s)

capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml), neutralization: 0.1-0.4 μg/mL

impurities

endotoxin, tested

isotype

IgG1

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NGF(4803)
mouse ... Ngf(18049)

Immunogen

recombinant human NGF-β.

Biochem/physiol Actions

Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using Protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
低风险生物材料

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Related Content


Josemberg S Baptista et al.
PloS one, 15(1), e0228155-e0228155 (2020-01-28)
Intervertebral disc (IVD) degeneration is a remodeling process mediated by several growth factors and cytokines. This process has been extensively studied in vitro and with pathologic specimens obtained during surgery for scoliosis or back pain. However, the occurrence and temporal
Elena Formaggio et al.
Neuroscience research, 62(1), 32-42 (2008-07-09)
In this work, we define a GFP-tagged version of the p75 neurotrophin receptor (p75GFP) as a useful molecular tool for studying its distribution and cellular dynamics. Expression and subcellular localization of p75GFP have been characterized in non-neuronal (HEK 293) and
R Judith et al.
Life sciences, 87(1-2), 1-8 (2010-05-18)
The objective of this study was to develop an acellular provisional matrix to mimic the extracellular matrix (ECM) of a wound site, and to evaluate its potential for in vivo dermal regeneration. This study evaluates the potential of a monomeric



Global Trade Item Number

SKUGTIN
N3279-.5MG04061832715032