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N4006

Naphthol AS-BI N-acetyl-β-D-glucosaminide

Name: Naphthol AS-BI N-acetyl-&#946;-<SC>D</SC>-glucosaminide
Brand: SIGMA

β-hexosaminidase substrate, ≥97% (TLC), powder

Synonym(s):

2-Naphthalenecarboxamide, 3-[[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-7-bromo-N-(2-methoxyphenyl)-, Naphthol AS-BI 2-acetamido-2-deoxy-β-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₇BrN₂O₈

CAS Number:

3395-37-7

Molecular Weight:

575.41

UNSPSC Code:

12352204

PubChem Substance ID:

24897360

NACRES:

NA.83

MDL number:

MFCD00076131

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Properties

Product Name

Naphthol AS-BI N-acetyl-β-D-glucosaminide, β-hexosaminidase substrate

Quality Level

200

assay

≥97% (TLC)

form

powder

solubility

DMF: 50 mg/mL

storage temp.

−20°C

SMILES string

COc1ccccc1NC(=O)c2cc3cc(Br)ccc3cc2OC4OC(CO)C(O)C(O)C4NC(C)=O

InChI

1S/C26H27BrN2O8/c1-13(31)28-22-24(33)23(32)21(12-30)37-26(22)36-20-11-14-7-8-16(27)9-15(14)10-17(20)25(34)29-18-5-3-4-6-19(18)35-2/h3-11,21-24,26,30,32-33H,12H2,1-2H3,(H,28,31)(H,29,34)

InChI key

DMLKUPXKUQREOC-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The world is your oyster: low-dose, long-term microplastic exposure of juvenile oysters.

Maes Thomas et al.

Heliyon, 6(1), e03103-e03103 (2020-01-08)

Bivalve filter feeders, such as oysters, filter large volumes of water and are particularly exposed to microplastics (MP). Consequently, these animals digest and assimilate high levels of MP in their bodies that may likely impact their physiology, and potentially affect

Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3-kinase-protein kinase B pathway in diabetic rats.

Wei-Jian Ni et al.

Journal of diabetes investigation, 11(2), 297-306 (2019-07-25)

Amelioration of renal impairment is the key to diabetic nephropathy (DN) therapy. The progression of DN is closely related to podocyte dysfunction, but the detailed mechanism has not yet been clarified. The present study aimed to explore the renal impairment

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity.

Oeystein R Brekk et al.

Acta neuropathologica communications, 8(1), 127-127 (2020-08-09)

Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson's disease (PD). α-synuclein (aSYN) inclusions, the diagnostic hallmark sign of

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Global Trade Item Number

SKU	GTIN
N4006-100MG	04061833273166
N4006-1G	04061826692004