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N4751

Nicotinuric acid

Name: Nicotinuric acid
Brand: SIGMA

Synonym(s):

Nicotinylglycine

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About This Item

Empirical Formula (Hill Notation):

C₈H₈N₂O₃

CAS Number:

583-08-4

Molecular Weight:

180.16

NACRES:

NA.79

PubChem Substance ID:

24897709

UNSPSC Code:

12352106

EC Number:

209-497-0

MDL number:

MFCD00023578

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Properties

assay

≥98% (with NaOH, titration)

form

powder

color

white

SMILES string

OC(=O)CNC(=O)c1cccnc1

InChI

1S/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)

InChI key

ZBSGKPYXQINNGF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Nicotinuric acid (NUA) is a metabolite of niacin/vitamin B. Measurement of NUA levels in urine is used to indicate possible elevated nicotinamide adenine dinucleotide (NAD) catabolism. NUA may be used as a reference (standard curve) in the analysis of NAD and NUA catabolism. Nicotinic acid reduces triglycerides and increases high density lipoprotein(HDL) cholesterol.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man.

H L Figge et al.

Journal of clinical pharmacology, 28(12), 1136-1140 (1988-12-01)

We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten

Effect of Nicotinic Acid (Vitamin B3 or Niacin) on the lipid profile of diabetic and non-diabetic rats

Shah TZ, et al.

Pakistan Journal of Medical Sciences, 29(5), 1259-1259 (2013)

The bioavailability of sustained release nicotinic acid formulations.

P J Neuvonen et al.

British journal of clinical pharmacology, 32(4), 473-476 (1991-10-01)

1. The bioavailability of three nicotinic acid formulations was investigated in a randomized cross-over study. 2. Single doses of nicotinic acid (500 mg) were given to seven healthy volunteers. The concentrations of nicotinic acid and its main metabolite nicotinuric acid

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Global Trade Item Number

SKU	GTIN
N4751-5G	04061833612330