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N6252

Norharmane

Name: Norharmane
Brand: SIGMA

≥98% (TLC), crystalline, monoamine oxidase inhibitor

Synonym(s):

β-Carboline, 9H-Pyrido[3,4-b]indole

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₈N₂

CAS Number:

244-63-3

Molecular Weight:

168.19

NACRES:

NA.77

PubChem Substance ID:

24897776

UNSPSC Code:

12352200

EC Number:

205-959-0

MDL number:

MFCD00004956

Form:

crystalline

Quality level:

200

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Properties

Product Name

Norharmane, crystalline

form

crystalline

Quality Level

200

color

light yellow

storage temp.

2-8°C

SMILES string

c1ccc2c(c1)[nH]c3cnccc23

InChI

1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

InChI key

AIFRHYZBTHREPW-UHFFFAOYSA-N

Gene Information

human ... IKBKB(3551)
rat ... Gabra2(29706)

Description

General description

Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

Application

Norharmane has been used:

as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)

Biochem/physiol Actions

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Protocols

聚糖的质谱

该聚糖质谱分析方案，被称之为干液滴法，基于原始的MALDI实验并依然是MS领域中最常用的方法。

Mass Spectrometry of Glycans

Explore mass spectrometry analysis of glycans for glycomic & glycoproteomic neutral & acidic glycan analysis. See a general mass spec glycan analysis procedure.

Global Trade Item Number

SKU	GTIN
N6252-100MG	04061834117469
N6252-1G	04061826203415
N6252-500MG	04061832557564