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N7510

Nicardipine hydrochloride

≥98%, L-type voltage-dependent calcium channel blocker, powder

Synonym(s):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methyl(phenylmethyl)amino]ethyl ester hydrochloride, YC-93

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About This Item

Empirical Formula (Hill Notation):
C26H29N3O6 · HCl
CAS Number:
54527-84-3
Molecular Weight:
515.99
NACRES:
NA.77
PubChem Substance ID:
24277856
UNSPSC Code:
12352200
EC Number:
259-198-4
MDL number:
MFCD00057327
Assay:
≥98%
Form:
powder
Quality level:
100
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Product Name

Nicardipine hydrochloride, powder, ≥98%

Quality Level

100

assay

≥98%

form

powder

color

yellow

solubility

DMSO: ~1 mg/mL, 0.1 M NaOH: insoluble, H2O: slightly soluble, methanol: soluble

originator

EKR Therapeutics

storage temp.

2-8°C

SMILES string

Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3

InChI

1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H

InChI key

AIKVCUNQWYTVTO-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Biochem/physiol Actions

Blocks L-type voltage-dependent calcium channels; antihypertensive.

Features and Benefits

This compound was developed by EKR Therapeutics. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG9331
BCCF6860
BCCF6861
BCCF0785
BCBN3159V

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Prasanna P K M Gamage et al.
Journal of cellular and molecular medicine, 22(10), 5160-5164 (2018-07-27)
Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence. Interstitial cells of cajal (ICC) play an important role in regulation of intestinal smooth muscle contraction. However
S Thellung et al.
Neurobiology of disease, 7(4), 299-309 (2000-08-31)
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrP(Sc). A synthetic peptide homologous to residues 106-126 of PrP (PrP106-126) was reported to maintain the neurodegenerative characteristics of
I Japelj et al.
European journal of pharmacology, 369(1), 43-47 (1999-04-16)
The qualitative and quantitative effects of the (+)-S and (-)-R enantiomers and of the racemic mixture of the Ca2+ channel antagonist, nicardipine, were compared on the isolated porcine coronary artery with intact and removed endothelium. All three forms of nicardipine
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Global Trade Item Number

SKUGTIN
N7510-5G04061832962283
N7510-10G04061832962276
N7510-1G04061835506514