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N9876

4-Nitrophenyl butyrate

Name: 4-Nitrophenyl butyrate
Brand: SIGMA

lipase substrate, chromogenic, esterase substrate, ≥98%, liquid

Synonym(s):

p-Nitrophenyl butyrate, Butyric acid 4-nitrophenyl ester

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁NO₄

CAS Number:

2635-84-9

Molecular Weight:

209.20

NACRES:

NA.83

PubChem Substance ID:

24897915

UNSPSC Code:

12352204

MDL number:

MFCD00047734

Beilstein/REAXYS Number:

1879729

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Properties

Product Name

4-Nitrophenyl butyrate, ≥98%

Quality Level

200

assay

≥98%

form

liquid

density

1.19 g/mL at 20 °C (lit.)

storage temp.

−20°C

SMILES string

CCCC(=O)Oc1ccc(cc1)[N+]([O-])=O

InChI

1S/C10H11NO4/c1-2-3-10(12)15-9-6-4-8(5-7-9)11(13)14/h4-7H,2-3H2,1H3

InChI key

DVDUMIQZEUTAGK-UHFFFAOYSA-N

Description

General description

4-Nitrophenyl butyrate is a substrate for esterase, and lipase enzyme. Hydrolysis of 4-nitrophenyl butyrate by these enzymes releases the chromophore, 4-nitrophenolate which is spectrophotometrically analysed at 415 nm.

Application

4-nitrophenyl butyrate has been used:

as a substrate for esterase activity in monocyte-derived macrophage cell line in response to polyethylene
as a substrate for mycobacterial phospholipase A and mycobacterial cutinase activity
as a substrate to determine the effect of buffers and solvents on human carboxylesterase

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Lactic acid bacteria-fermented product of green tea and Houttuynia cordata leaves exerts anti-adipogenic and anti-obesity effects.

Li-Chun Wang et al.

Journal of food and drug analysis, 26(3), 973-984 (2018-07-07)

Obesity is associated with higher risks of developing diabetes and cardiovascular disease. Green tea, rich in polyphenolic compounds such as epigallocatechin gallate (EGCG) and epigallocatechin (EGC), has been shown to display anti-obesity effects. Houttuynia cordata leaves have also been shown

Immobilization of lipase from Pseudomonas fluorescens on glyoxyl-octyl-agarose beads: Improved stability and reusability.

Nathalia S Rios et al.

Biochimica et biophysica acta. Proteins and proteomics, 1867(9), 741-747 (2019-06-16)

The lipase from Pseudomonas fluorescens (PFL) has been immobilized on glyoxyl-octyl agarose and compared to the enzyme immobilized on octyl-agarose. Thus, PFL was immobilized at pH 7 on glyoxyl-octyl support via lipase interfacial activation and later incubated at pH 10.5 for 20 h

Differential response to chemically altered polyethylene by activated mature human monocyte-derived macrophages

Xing S, et al.

Biomaterials, 23(17), 3595-3602 (2002)

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Global Trade Item Number

SKU	GTIN
N9876-1G	04061835558209
N9876-10G	04061838505170
N9876-5G	04061834118947