O0383
N-Oleoylethanolamine
~98% (TLC), PPARα agonist, powder
Synonym(s):
N-(Hydroxyethyl)oleamide, N-(cis-9-Octadecenoyl)ethanolamine, OEA, oleoylethanolamide
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About This Item
Empirical Formula (Hill Notation):
C20H39NO2
CAS Number:
Molecular Weight:
325.53
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
203-884-8
MDL number:
Product Name
N-Oleoylethanolamine, ~98% (TLC)
assay
~98% (TLC)
Quality Level
form
powder
solubility
chloroform: 20 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
O=C(CCCCCCC/C=C\CCCCCCCC)NCCO
InChI
1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
InChI key
BOWVQLFMWHZBEF-KTKRTIGZSA-N
Gene Information
human ... CNR1(1268), CNR2(1269), PPARA(5465), TRPV1(7442)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)
General description
Oleoylethanolamide (OEA) is an endogenous fatty acid ethanolamine. Small intestine cells, adipose tissues, neurons and astrocytes produces OEA.
Application
N-Oleoylethanolamine has been used to study its effects on glucagon-like peptide (GLP)-1RA-mediated anorectic signaling and weight loss.
Biochem/physiol Actions
Oleoylethanolamide (OEA) is a lipid mediator, which helps to control various biological functions, like food intake. It modulates the gene expression in the small intestine. OEA has the ability to initiate several receptors, such as cannabinoid receptor type 1 (CB1), peroxisome proliferator-activated receptors (PPARs) and G protein-coupled receptor 119 (GPR119).
Peroxisome proliferator-activator receptor α (PPARα) agonist
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Storage Class
11 - Combustible Solids
ppe
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Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice
Brown JD, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 315(4), R595-R608 (2018)
Sandrine Lecour et al.
Journal of molecular and cellular cardiology, 34(5), 509-518 (2002-06-12)
TNF alpha administration mimics ischemic preconditioning and neutralizing antibodies to TNF alpha and IL-1 beta abolish exercise-induced preconditioning. However, the pharmacology of TNF alpha's cardioprotective effects and associated downstream signaling events has not been delineated. We evaluated the temporal and
Carolina Yudes et al.
International journal of environmental research and public health, 17(11) (2020-06-07)
(1) Cyberbullying has gained increased attention from society and researchers due both to its negative psychosocial consequences and the problems that have risen relating to the misuse of technology. Despite the growing number of scientific studies, most research has focused
Global Trade Item Number
| SKU | GTIN |
|---|---|
| O0383-10MG | 04061834212591 |
| O0383-25MG | 04061834212614 |