O9637
Oxaprozin
solid
Synonym(s):
4,5-Diphenyl-2-oxazolepropanoic acid, Daypro
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About This Item
Empirical Formula (Hill Notation):
C18H15NO3
CAS Number:
Molecular Weight:
293.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-296-1
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
SMILES string
OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3
InChI
1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChI key
OFPXSFXSNFPTHF-UHFFFAOYSA-N
Gene Information
human ... PTGIR(5739), PTGS1(5742), PTGS2(5743)
General description
Oxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA). Oxaprozin binds to albumin. It inhibits arachidonic acid pathway. Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.
Application
Anti-inflammatory
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Articles
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Seda G Sagdinc et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75(4), 1370-1376 (2010-02-20)
The molecular structure, linear and nonlinear optical properties, and electronic properties of 4,5-diphenyl-2-2 oxazole propionic acid (oxaprozin) as a monomer were investigated by using Hartree-Fock (HF) and density functional theory (DFT) calculations that used 6-31G(d,p) basis set. The first-order hyperpolarizability
N Bellamy et al.
Current medical research and opinion, 15(2), 121-127 (1999-09-24)
Although progress has been made in the clinical metrology of pain in rheumatoid arthritis, much further work remains. The preferred methods of measurement remain debatable. In this longitudinal, open study, a comparison of eight self-rating pain scales has been conducted.
Bojan D J Božić et al.
Chemical & pharmaceutical bulletin, 60(7), 865-869 (2012-07-14)
A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized. The drug and complexes have been characterized by elemental and thermogravimetric (TG) analysis, Fourier transform (FT)-IR, 1H-NMR, 13C-NMR, UV-Vis
Global Trade Item Number
| SKU | GTIN |
|---|---|
| O9637-5MG | 04061832632353 |