P0022
PS48
≥98% (HPLC)
Synonym(s):
5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
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About This Item
Empirical Formula (Hill Notation):
C17H15ClO2
CAS Number:
Molecular Weight:
286.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2
InChI
1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
InChI key
LLJYFDRQFPQGNY-QINSGFPZSA-N
Biochem/physiol Actions
PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site.
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mito Kanatsu-Shinohara et al.
The Journal of reproduction and development, 64(6), 511-522 (2018-09-04)
Stem cell homing is a complex phenomenon that involves multiple steps; thus far, attempts to increase homing efficiency have met with limited success. Spermatogonial stem cells (SSCs) migrate to the niche after microinjection into seminiferous tubules, but the homing efficiency
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P0022-25MG | 04061833219942 |
| P0022-5MG | 04061833219959 |