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P0500

Palmitic acid

Name: Palmitic acid
Brand: SIGMA

≥99%

Synonym(s):

1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH

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About This Item

Linear Formula:

CH₃(CH₂)₁₄COOH

CAS Number:

57-10-3

Molecular Weight:

256.42

UNSPSC Code:

12352106

NACRES:

NA.25

PubChem Substance ID:

24898107

EC Number:

200-312-9

Beilstein/REAXYS Number:

607489

MDL number:

MFCD00002747

Assay:

≥99%

Concentration:

≥99%

Form:

powder

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Properties

vapor pressure

10 mmHg ( 210 °C)

Quality Level

200

assay

≥99%

form

powder

concentration

≥99%

bp

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

solubility

water: soluble 0,00005 g/L at 20 °C

density

0.852 g/mL at 25 °C (lit.)

functional group

carboxylic acid

lipid type

saturated FAs

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPCSVZSSVZVIGE-UHFFFAOYSA-N

Gene Information

human ... FABP2(2169), FABP3(2170), FABP4(2167), FABP5(2171)

Description

General description

Palmitic acid (PA), a saturated fatty acid present in the human body, accounts for 20-30% of total fatty acids (FA) in membrane phospholipids (PL) and adipose triacylglycerols (TAG). It is one of the main components of palm oil however, significant amounts of PA are also found in meat and dairy products, cocoa butter, and olive oil. PA is also present in breast milk. PA performs various fundamental biological functions at cellular and tissue levels.

Application

Palmitic acid has been used:

to study its effects on monocyte chemoattractant protein-1 (MCP-1) expression in adipocytes and THP-1 macrophages
to stimulate lipotoxicity in primary rat hepatocytes
in Et-bovine serum albumin (BSA) solution along with retinoic acid (RA) and retinol to study its effects on spermatogenesis or meiotic progression

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Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

235.4 °F

flash_point_c

113 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Articles

棕榈酸在细胞培养中的应用

棕榈酸等脂肪酸和其他细胞培养成分如何影响无血清、无蛋白细胞培养系统（用于生物制造包括单克隆抗体在内的异源蛋白）的性能。

Palmitic Acid in Cell Culture

How palmitic acid, other fatty acids and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

Stearic Acid in Cell Culture

Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy.

Jorge Matias Caviglia et al.

Journal of lipid research, 52(9), 1636-1651 (2011-07-02)

Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER

tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation.

Songtao Li et al.

Biochimica et biophysica acta, 1841(1), 22-33 (2013-09-24)

Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective strategy against

The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes.

Chen Shen et al.

Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)

Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the

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Global Trade Item Number

SKU	GTIN
P0500-10G	04061835547234
P0500-100G	04061835547227
P0500-250G	04061832864921
P0500-25G	04061835547241

Key Documents

Palmitic acid

≥99%

Select a Size

About This Item

vapor pressure

Quality Level

assay

form

concentration

bp

mp

solubility

density

functional group

lipid type

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

General description

Application

Still not finding the right product?

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

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Protocols and Articles

Articles

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Global Trade Item Number