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About This Item
Empirical Formula (Hill Notation):
C16H18N6O4
CAS Number:
Molecular Weight:
358.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
>97%
form
solid
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.6 mg/mL, H2O: insoluble, absolute ethanol: slightly soluble, ethanol: water (1:1): soluble, methanol: soluble (hot)
storage temp.
−20°C
SMILES string
Nc1nc(Nc2ccccc2)nc3n(cnc13)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O
InChI
1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1
InChI key
SCNILGOVBBRMBK-SDBHATRESA-N
Gene Information
human ... ADORA2A(135), ADORA2B(136)
rat ... Adora1(29290), Adora2a(25369)
Biochem/physiol Actions
Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes.
Preparation Note
Solutions should be freshly prepared.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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D A Taylor et al.
European journal of pharmacology, 85(3-4), 335-338 (1982-12-03)
2-Chloroadenosine (2-CADO) and 2-phenylaminoadenosine (CV 1808) were compared in a CNS purinergic receptor binding assay and the inhibition of neurogenic contractions of the vas deferens. Both 2-CADO and CV 1808 are more potent than adenosine in both preparations. CV 1808
P H Wu et al.
General pharmacology, 15(3), 251-254 (1984-01-01)
Various adenosine derivatives, methylxanthines and other compounds were tested for their abilities to inhibit the rapid uptake of adenosine by rat cerebral cortical synaptosomes. Several pharmacologically potent derivatives of adenosine were weak inhibitors of uptake with IC20 values in excess
J W Phillis et al.
Pharmacology, biochemistry, and behavior, 24(2), 263-270 (1986-02-01)
Mice were implanted with chronic indwelling cannulae in the lateral cerebral ventricle. A series of adenosine analogs and related compounds were injected into the lateral ventricle (ICVT) and their effects on spontaneous locomotor activity recorded. All analogs produced dose-related decreases
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P101-5MG | 04061834353645 |
| P101-25MG | 04061832083537 |