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P1793

Pimozide

Name: Pimozide
Brand: SIGMA

≥98% (TLC), powder, D₂ dopamine receptor antagonist

Synonym(s):

1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₉F₂N₃O

CAS Number:

2062-78-4

Molecular Weight:

461.55

NACRES:

NA.77

PubChem Substance ID:

24277923

UNSPSC Code:

12352200

EC Number:

218-171-7

MDL number:

MFCD00055081

Form:

powder

Quality level:

200

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Properties

Product Name

Pimozide,

form

powder

Quality Level

200

solubility

DMSO: 18 mg/mL(lit.), chloroform: 5 mg/mL, H₂O: insoluble(lit.)

originator

Teva

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5

InChI

1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

InChI key

YVUQSNJEYSNKRX-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243), CACNA1G(8913), CYP3A4(1576), DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR7(3363), KCNH1(3756), KCNH2(3757), OPRD1(4985)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Scnn1g(24768)

Description

Biochem/physiol Actions

D₂ dopamine receptor antagonist; binds with high affinity to the cloned 5-HT₇ receptor; Ca²⁺ channel antagonist; antipsychotic

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Pimozide augmentation of clozapine inpatients with schizophrenia and schizoaffective disorder unresponsive to clozapine monotherapy.

Joseph I Friedman et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(6), 1289-1295 (2011-02-25)

Despite its superior efficacy, clozapine is helpful in only a subset of patients with schizophrenia unresponsive to other antipsychotics. This lack of complete success has prompted the frequent use of various clozapine combination strategies despite a paucity of evidence from

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.

Junjun Chen et al.

Chemistry & biology, 18(11), 1390-1400 (2011-11-29)

Ubiquitin-specific proteases (USPs) have in recent years emerged as a promising therapeutic target class. We identified selective small-molecule inhibitors against a deubiquitinase complex, the human USP1/UAF1, through quantitative high throughput screening (qHTS) of a collection of bioactive molecules. The top

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

Holger H H Erb et al.

PloS one, 15(8), e0237248-e0237248 (2020-08-14)

Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of transcription (STAT) 5 plays a role in tumour progression and

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Global Trade Item Number

SKU	GTIN
P1793-1G	04061825982625
P1793-500MG	04061832092553