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P1941

Poly(D,L-lactide-co-glycolide)

Name: Poly(<SC>D</SC>,<SC>L</SC>-lactide-<I>co</I>-glycolide)
Brand: SIGMA

lactide:glycolide (75:25), mol wt 66,000-107,000

Synonym(s):

LACTEL^® B6007-1, PLGA

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About This Item

Linear Formula:

[C₃H₄O₂]_x[C₂H₂O₂]_y

UNSPSC Code:

12162002

PubChem Substance ID:

24898256

NACRES:

NA.26

MDL number:

MFCD00131930

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Properties

form

pellets

Quality Level

100

feed ratio

lactide:glycolide (75:25)

mol wt

66,000-107,000

storage temp.

−20°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

InChI key

XBBVURRQGJPTHH-UHFFFAOYSA-N

Description

General description

The product is an amorphous solid with a transition temperature (Tg) in the range of 45-50°C. It is soluble in most organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroispropanol.

Application

Poly(D,L-lactide-co-glycolide) is a synthetic amino acid that has been used to deliver macromolecular therapeutics.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Biodegradable Aliphatic Polyesters for Drug Delivery

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo

Werner E.G.Muller

Acta Biomaterialia, 50, 89-101 (2017)

Effect of water on exenatide acylation in poly(lactide-co-glycolide) microspheres.

Rongcai Liang et al.

International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)

Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative

Induction of long-lasting protective immunity against Toxoplasma gondii in BALB/c mice by recombinant surface antigen 1 protein encapsulated in poly (lactide-co-glycolide) microparticles.

Shu-Chun Chuang et al.

Parasites & vectors, 6, 34-34 (2013-02-13)

Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or

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Global Trade Item Number

SKU	GTIN
P1941-1G	04061834357322
P1941-5G	04061834357346