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P2191

Poly(D,L-lactide-co-glycolide)

Name: Poly(<SC>D</SC>,<SC>L</SC>-lactide-<I>co</I>-glycolide)
Brand: SIGMA

lactide:glycolide (50:50), mol wt 30,000-60,000

Synonym(s):

LACTEL^® B6010-2, PLGA

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About This Item

Linear Formula:

[C₃H₄O₂]_x[C₂H₂O₂]_y

UNSPSC Code:

12352211

PubChem Substance ID:

24898286

NACRES:

NA.25

MDL number:

MFCD00131930

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Properties

feed ratio

lactide:glycolide (50:50)

Quality Level

100

mol wt

30,000-60,000

storage temp.

−20°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

InChI key

XBBVURRQGJPTHH-UHFFFAOYSA-N

Description

General description

Poly(D,L-lactide-co-glycolide) is a biodegradable and biocompatible polymer, which is used for drug delivery. It is used to treat rheumatoid arthritis, ulcerative colitis, Crohn′s disease, inflammatory lung diseases and ophthalmic inflammatory disorders. Poly(D,L-lactide-co-glycolide) functions as a potential cancer therapeutic target.

Application

Poly(D,L-lactide-co-glycolide) has been used to raise and sustain an increased lactate monomer level in the gel at a concentration relevant to dermal wounds.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms

Hunt TK, et al.

Antioxidants & Redox Signaling, 9(8), 1115-1124 (2007)

Thymoquinone-PLGA-PVA Nanoparticles Ameliorate Bleomycin-Induced Pulmonary Fibrosis in Rats via Regulation of Inflammatory Cytokines and iNOS Signaling.

Sultan A M Saghir et al.

Animals : an open access journal from MDPI, 9(11) (2019-11-14)

Pulmonary fibrosis is considered one of the most chronic interstitial illnesses which are not easily treated. thymoquinone's (TQ) benefits are still partly problematic due to poor water solubility; therefore, it was loaded onto PLGA-PVA carriers. This study aimed to evaluate

PLGA-based nanoparticles: an overview of biomedical applications

Danhier F, et al.

Journal of Controlled Release : Official Journal of the Controlled Release Society, 161(2), 505-522 (2012)

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Global Trade Item Number

SKU	GTIN
P2191-1G	04061835513932
P2191-5G	04061835513949