P2297
Picrylsulfonic acid solution
5 % (w/v) in H2O, BioReagent, suitable for determination of primary amines
Synonym(s):
2,4,6-Trinitrobenzenesulfonic acid solution, TNBS
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About This Item
Empirical Formula (Hill Notation):
C6H3N3O9S
CAS Number:
Molecular Weight:
293.17
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
572358
Concentration:
5 % (w/v) in H2O
Form:
liquid
product line
BioReagent
Quality Level
form
liquid
concentration
5 % (w/v) in H2O
solubility
soluble
suitability
suitable for determination of primary amines
storage temp.
2-8°C
SMILES string
OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
InChI
1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)
InChI key
NHJVRSWLHSJWIN-UHFFFAOYSA-N
General description
Picrylsulfonic acid solution is a hapten, which can bind to tissue proteins and turn into an antigen. This leads to several immunologic responses. Colitis induced by a 2,4,6-trinitrobenzene sulfonic acid (TNBS) is a type of delayed hypersensitivity reaction to haptenized proteins. Leukotriene B4 (LTB4) and the monhydroxyl fatty acids 5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE are the major inflammatory mediators involved in this TNBS-induced colitis. Ethanol when used in high concentration act as a vehicle for the TNBS administration.
Application
Hydrophilic modifying reagent. Derivatives with amino compounds can be regenerated with hydrazine.
Picrylsulfonic acid solution has been used:
- to assess the efficiency of carboxymethyl lysine (CML) modifications of exposed primary amines
- to incubate zona intact bovine embryos for the differential staining of blastocysts
- to induce irritable bowel syndrome (IBS) in mice and to study its effects on Clostridium butyricum
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
Storage Class
8B - Non-combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mara Perrone et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 115, 168-176 (2017-03-10)
The aim of this study was to synthesize, characterize and evaluate the mucoadhesive properties of the first thiolated hyperbranched natural polysaccharide with biodegradability and biocompatibility features. In detail, glycogen-cysteamine conjugates were synthesized through a first step of oxidative ring opening
Jiuzhi Xu et al.
The EMBO journal, 39(7), e103255-e103255 (2020-03-05)
The Hippo-YAP signaling pathway plays an essential role in epithelial cells during intestinal regeneration and tumorigenesis. However, the molecular mechanism linking stromal signals to YAP-mediated intestinal regeneration and tumorigenesis is poorly defined. Here, we report a stroma-epithelium ISLR-YAP signaling axis
Joel Castro et al.
Gastroenterology, 145(6), 1334-1346 (2013-08-21)
Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. We
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P2297-10ML | 04061838100603 |
| P2297-5X10ML | 04061838094216 |