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P3075

Phenylarsine oxide

Name: Phenylarsine oxide
Brand: SIGMA

synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder

Synonym(s):

Arzene, Oxophenylarsine, PAO

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About This Item

Empirical Formula (Hill Notation):

C₆H₅AsO

CAS Number:

637-03-6

Molecular Weight:

168.02

NACRES:

NA.77

PubChem Substance ID:

24898387

UNSPSC Code:

12352119

EC Number:

211-275-3

MDL number:

MFCD00001990

Beilstein/REAXYS Number:

2935227

Assay:

≥97%

Form:

powder

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Properties

Product Name

Phenylarsine oxide, ≥97%, powder

biological source

synthetic (organic)

assay

≥97%

form

powder

color

white to off-white

mp

145-148 °C

solubility

DMSO: 50 mg/mL

SMILES string

O=[As]c1ccccc1

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

Description

General description

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem/physiol Actions

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.