P3755
6-Propyl-2-thiouracil
≥99% (HPLC), powder
Synonym(s):
2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine
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About This Item
Empirical Formula (Hill Notation):
C7H10N2OS
CAS Number:
Molecular Weight:
170.23
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-103-2
MDL number:
Beilstein/REAXYS Number:
130039
Assay:
≥99% (HPLC)
Form:
powder
Solubility:
10% NH3: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
Product Name
6-Propyl-2-thiouracil, enzyme inhibitor
Quality Level
assay
≥99% (HPLC)
form
powder
mp
218-220 °C (lit.)
solubility
10% NH3: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
CCCC1=CC(=O)NC(=S)N1
InChI
1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
InChI key
KNAHARQHSZJURB-UHFFFAOYSA-N
Gene Information
human ... DIO1(1733), TPO(7173)
General description
6-Propyl-2-thiouracil or 6-n-Propylthiouracil (PROP) is a compound with a bitter taste.
Application
6-Propyl-2-thiouracil (PROP) has been used to impregnate on disk for PROP taster status studies for sensory characterization in a defined human sample group. It has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).
6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, high performance liquid chromatography (HPLC), or gas chromatography.
Biochem/physiol Actions
6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Related Content
Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil
Goldstein G L, et al.
Obesity Research, 13(6), 1017-1023 (2005)
Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil
Kuiper George GJM, et al.
Endocrinology, 147(7), 3519-3529 (2006)
Louise Ramhøj et al.
PeerJ, 7, e7181-e7181 (2019-07-11)
Relative gene expression data obtained from quantitative RT-PCR (RT-qPCR) experiments are dependent on appropriate normalization to represent true values. It is common to use constitutively expressed endogenous reference genes (RGs) for normalization, but for this strategy to be valid the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P3755-100G | 04061834372882 |
| P3755-25G | 04061834372905 |
| P3755-10G | 04061834372899 |