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P4538

Poly-L-ornithine hydrobromide

Name: Poly-<SC>L</SC>-ornithine hydrobromide
Brand: SIGMA

Mol wt 5,000-15,000

Synonym(s):

L-Ornithine homopolymer hydrobromide

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About This Item

CAS Number:

27378-49-0

UNSPSC Code:

12352209

NACRES:

NA.26

MDL number:

MFCD00237231

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Properties

Product Name

Poly-L-ornithine hydrobromide, mol wt 5,000-15,000

form

powder

Quality Level

200

mol wt

5,000-15,000

color

white to off-white

storage temp.

−20°C

SMILES string

[Br-].NC(CCCN)C(=O)O.[H+]

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

InChI key

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

Description

Application

Thermodynamic Characterization of Polypeptide Complex Coacervation.: The research investigates the thermodynamic properties of polypeptide complex coacervation, including the role of Poly-L-ornithine hydrobromide in these interactions. This study provides insights into the self-assembly processes of polypeptides, which are crucial for designing new biomaterials (Priftis et al., 2012).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

L-Ornithine in Cell Culture

Discover L-ornithine, an important amino acid supplement, explore how L-ornithine is used in CHO and iPSC culture, and discover how poly-L-ornithine is used to enhance cell attachment.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro.

E Ramsay et al.

International journal of pharmaceutics, 210(1-2), 97-107 (2001-02-13)

The impetus to develop non-viral gene delivery vectors has led to examination of synthetic polycationic polymers as plasmid DNA (pDNA) condensing agents. Previous reports have highlighted superiority (up to x 10-fold) in the in-vitro transfection of pDNA complexes formed by

New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch.

J P McQuilling et al.

Transplantation proceedings, 43(9), 3262-3264 (2011-11-22)

Severe hypoxia caused by a lack of vascular supply and an inability to retrieve encapsulated islets transplanted in the peritoneal cavity for biopsy and subsequent evaluation are obstacles to clinical application of encapsulation strategies for islet transplantation. We recently proposed

Polylysine and polyornithine gene transfer complexes: a study of complex stability and cellular uptake as a basis for their differential in-vitro transfection efficiency.