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P4562

Sodium pyruvate

Name: Sodium pyruvate
Brand: SIGMA

powder, BioXtra, suitable for mouse embryo cell culture

Synonym(s):

α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt

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About This Item

Linear Formula:

CH₃COCOONa

CAS Number:

113-24-6

Molecular Weight:

110.04

UNSPSC Code:

12352207

NACRES:

NA.75

PubChem Substance ID:

24898552

EC Number:

204-024-4

Beilstein/REAXYS Number:

3568341

MDL number:

MFCD00002586

Assay:

≥99%

Form:

powder

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Properties

product line

BioXtra

Quality Level

200

assay

≥99%

form

powder

technique(s)

cell culture | embryo: suitable

mp

>300 °C (lit.)

solubility

H₂O: 100 mg/mL

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

Description

General description

Pyruvate, the end-product of the glycolysis pathway, is the anion of pyruvic acid.

Application

Sodium pyruvate has been used:

as a supplement in Ca²⁺ + N-Tris(hydroxymethil)methyl-2-aminoethanesulfonic acid (TES)–NaCl medium for sperm incubation
as a supplement in TCM-199 hepes modification solution for cumulus-oocytes complexes (COC′s) culture
as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture mouse primary hepatocytes (MPHs) and also to intraperitoneally inject fasted mice for glucose production assessment

Biochem/physiol Actions

Sodium pyruvate is mainly used as a constituent in culture broth and media. It exhibits anti-oxidation and anti-inflammatory properties. Hence sodium pyruvate is considered a possible therapy for allergic rhinitis. Sodium pyruvate might also be a new approach treating lactic acidosis.

Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. Sodium pyruvate attenuates oxidative stress in vitro. The 100 mM solution should be diluted at 1:100 for most cell culture applications. This product has been qualified for use in mouse embryo cultures.