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P4663

Poly-L-arginine hydrochloride

mol wt 5,000-15,000

Synonym(s):

L-Arginine homopolymer hydrochloride

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About This Item

CAS Number:
26982-20-7
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24898490
NACRES:
NA.26
MDL number:
MFCD00166393
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form

powder

Quality Level

200

mol wt

5,000-15,000

color

white to off-white

application(s)

cell analysis
detection

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

Application


  • Interfacial Electrostatics of Poly(vinylamine hydrochloride), Poly(diallyldimethylammonium chloride), Poly-L-lysine, and Poly-L-arginine Interacting with Lipid Bilayers.: This research investigates the interactions between poly-L-arginine hydrochloride and lipid bilayers, providing insights into its potential applications in drug delivery systems (McGeachy et al., 2018). (McGeachy et al., 2018).

Analysis Note

Contains 3% or less ornithine residue.
Molecular weight based on viscosity of precursor poly-L-ornithine.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLBF2407V
111M5012V
071M5001
071M5001V
055K51082

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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
Ohtake K, Natsume H, Ueda H, et al.
J. Controlled Release, 82, 263-275 (2002)
Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 1838-1845 (2003)
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
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Global Trade Item Number

SKUGTIN
P4663-100MG04061834375029
P4663-10MG04061832780122
P4663-50MG04061832780139