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P6273

2-Propylpentanoic acid

Name: 2-Propylpentanoic acid
Brand: SIGMA

Synonym(s):

Valproic acid

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About This Item

Linear Formula:

(CH₃CH₂CH₂)₂CHCO₂H

CAS Number:

99-66-1

Molecular Weight:

144.21

NACRES:

NA.25

PubChem Substance ID:

24898751

UNSPSC Code:

12352211

EC Number:

202-777-3

MDL number:

MFCD00002672

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Properties

Quality Level

200

refractive index

n20/D 1.425 (lit.)

bp

220 °C (lit.)

solubility

H₂O: slightly soluble, alcohol: soluble

density

0.9 g/mL at 25 °C (lit.)

lipid type

saturated FAs

SMILES string

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

InChI key

NIJJYAXOARWZEE-UHFFFAOYSA-N

Gene Information

human ... ALDH5A1(7915), CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)

Description

Application

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Biochem/physiol Actions

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

pictograms

GHS08,GHS05,GHS07

signalword

Danger

hcodes

H302,H315,H318,H360FD

pcodes

P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

231.8 °F - closed cup

flash_point_c

111 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Efficient generation of nonhuman primate induced pluripotent stem cells.

Bonan Zhong et al.

Stem cells and development, 20(5), 795-807 (2010-11-10)

Induced pluripotent stem (iPS) cells have great potential for regenerative medicine and gene therapy. Thus far, iPS cells have typically been generated using integrating viral vectors expressing various reprogramming transcription factors; nonintegrating methods have been less effective and efficient. Because

Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell linesin vitro

Cuijie S, et al.

Chinese Medical Journal (English Edition), 125(24), 4338-4343 (2012)

3-Heptanone as a potential new marker for valproic acid therapy

Erhart S, et al.

Journal of Breath Research, 3(1), 016004-016004 (2009)

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Global Trade Item Number

SKU	GTIN
P6273-100ML	04061834393207