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P8692

Paromomycin sulfate salt

Name: Paromomycin sulfate salt
Brand: SIGMA

powder, suitable for plant cell culture, BioReagent

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₄₅N₅O₁₄ · xH₂SO₄

CAS Number:

1263-89-4

Molecular Weight:

615.63 (free base basis)

UNSPSC Code:

10171502

PubChem Substance ID:

24898967

NACRES:

NA.72

Beilstein/REAXYS Number:

5715182

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Properties

Product Name

Paromomycin sulfate salt, suitable for plant cell culture, BioReagent

product line

BioReagent

Quality Level

200

form

powder

technique(s)

cell culture | plant: suitable

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

application(s)

agriculture

mode of action

protein synthesis | interferes

SMILES string

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OYJABWUHUYVDMJ-UDXJMMFXSA-N

Description

General description

Chemical structure: aminoglycoside

Application

Paromomycin, monomycin, is an aminoglycoside antibiotic used to select genetically transformed plants and plant cells.

Biochem/physiol Actions

Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth.
Mode of Action: Inhibits initiation and elongation during protein synthesis.

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Packaging

5g,25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

Global Trade Item Number

SKU	GTIN
P8692-25G	04061834401667
P8692-5G	04061834401674