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P8765

Ammonium pyrrolidinedithiocarbamate

Name: Ammonium pyrrolidinedithiocarbamate
Brand: SIGMA

~99%

Synonym(s):

1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC

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About This Item

Linear Formula:

C₅H₉NS₂ · NH₃

CAS Number:

5108-96-3

Molecular Weight:

164.29

UNSPSC Code:

12352107

NACRES:

NA.77

PubChem Substance ID:

24278658

EC Number:

225-834-4

Beilstein/REAXYS Number:

3730472

MDL number:

MFCD00012720

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Properties

biological source

microbial

Quality Level

200

assay

~99%

form

(powderor powder with lumps)

mp

153-155 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

N.SC(=S)N1CCCC1

InChI

1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3

InChI key

MDDIUTVUBYEEEM-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846), RELA(5970)

Description

General description

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Application

Ammonium pyrrolidinedithiocarbamate has been used:

to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
to reduce neutrophil activity in rats
to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage

Friedrich V, et al.

Journal of Neuroinflammation, 8(1), 103-103 (2011)

Multi-element preconcentration of heavy metal ions from aqueous solution by APDC impregnated activated carbon

Daorattanachai P, et al.

Talanta, 67(1), 59-64 (2005)

Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells

Tsai JC, et al.

The Journal of Biological Chemistry, 271(7), 3667-3670 (1996)

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Global Trade Item Number

SKU	GTIN
P8765-1G	04061834401759
P8765-25G	04061834401766
P8765-100G	04061835522477
P8765-5G	04061834401773

Key Documents

Ammonium pyrrolidinedithiocarbamate

~99%

Select a Size

About This Item

biological source

Quality Level

assay

form

mp

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

General description

Application

Biochem/physiol Actions

Still not finding the right product?

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Global Trade Item Number