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P9159

Piperidine-4-sulfonic acid

Name: Piperidine-4-sulfonic acid
Brand: SIGMA

Synonym(s):

P4S

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About This Item

Empirical Formula (Hill Notation):

C₅H₁₁NO₃S

CAS Number:

72450-62-5

Molecular Weight:

165.21

NACRES:

NA.77

PubChem Substance ID:

24278165

UNSPSC Code:

12352106

MDL number:

MFCD00055097

Form:

powder

Quality level:

200

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Properties

form

powder

Quality Level

200

SMILES string

OS(=O)(=O)C1CCNCC1

InChI

1S/C5H11NO3S/c7-10(8,9)5-1-3-6-4-2-5/h5-6H,1-4H2,(H,7,8,9)

InChI key

UGBJGGRINDTHIH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

Biochem/physiol Actions

GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

Propofol increases agonist efficacy at the GABA(A) receptor.

S M O'Shea et al.

Brain research, 852(2), 344-348 (2000-03-11)

Using the whole-cell patch-clamp technique, we have determined that propofol, but not midazolam, increases the efficacy of piperidine-4-sulphonic acid (P4S), a partial agonist at alpha1beta1gamma2s, GABA(A) receptors expressed in HEK 293 cells. These findings are consistent with the idea that

Role of the fastigial nucleus in generalized seizures as demonstrated by GABA agonist microinjections.

J W Miller et al.

Epilepsia, 34(6), 973-978 (1993-11-01)

The cerebellum is electrically and metabolically active during seizures. Numerous studies have also shown that cerebellar electrical stimulation and lesions of the cerebellar cortex or nuclei influence seizure threshold, but there are significant contradictions, with different effects observed even in

Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.

B Ebert et al.

Molecular pharmacology, 52(6), 1150-1156 (1997-12-16)

Using human gamma-aminobutyric acid type A (GABAA) receptor subunit combinations, expressed in cell lines and Xenopus laevis oocytes, the pharmacology of a number of ligands interacting directly with the GABA recognition site has been studied in [3H]muscimol binding and electrophysiologically.

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Global Trade Item Number

SKU	GTIN
P9159-250MG	04061832083704
P9159-25MG	04061832083711