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R0158

RepSox

Name: RepSox
Brand: SIGMA

≥98% (HPLC), solid, TGF-β RI kinase inhibitor

Synonym(s):

E-616452; 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₃N₅

CAS Number:

446859-33-2

Molecular Weight:

287.32

UNSPSC Code:

51111800

PubChem Substance ID:

329823975

NACRES:

NA.77

MDL number:

MFCD09037561

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Product Name

RepSox, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3

InChI

1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

InChI key

LBPKYPYHDKKRFS-UHFFFAOYSA-N

Description

Application

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Biochem/physiol Actions

RepSox inhibits osteoclast differentiation, resorption in bone tissues and ovariectomy (OVX)‐induced osteoporosis (OP) through repression of the SMAD family member 3 (Smad3) and c-Jun N-terminal kinase (JNK) pathway/ activator protein 1 (AP-1) pathways.

RepSox Inhibits TGF-beta receptor signaling.

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors

Krentz N, et al.

Developmental Cell, 41(2), 129-142 (2017)

Small molecule inhibitor RepSox prevented ovariectomy-induced osteoporosis by suppressing osteoclast differentiation and bone resorption

Mei L, et al.

Journal of Cellular Physiology, 233(12) (2018)

Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype

Hopkinson B, et al.

Testing, 8(6), 10580-10580 (2017)

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Global Trade Item Number

SKU	GTIN
R0158-25MG	04061833221082
R0158-5MG	04061836693749