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Merck
CN

R6000

Ribonuclease S from bovine pancreas

Grade XII-S

Synonym(s):

RNase S, pancreatic RNase, protease-modified RNase A

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About This Item

CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-646-6
MDL number:
Specific activity:
≥60 Kunitz units/mg solid
Biological source:
bovine pancreas
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biological source

bovine pancreas

Quality Level

type

Grade XII-S

form

powder

specific activity

≥60 Kunitz units/mg solid

mol wt

13.7 kDa

storage temp.

−20°C

SMILES string

[nH]1cnc(c1)CC(NC(=O)CCN)C(=O)O

InChI

1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)

InChI key

CQOVPNPJLQNMDC-UHFFFAOYSA-N

Application

Ribonuclease S from bovine pancreas has been used in a study to assess the hybridase activity of human ribonuclease-1. Ribonuclease S from bovine pancreas has also been used in a study to investigate a new approach to obtaining high-activity RNase, DNase, cholesterolesterase, and trypsin from cattle pancreas.

Other Notes

Protease-modified RNase A


pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Beata Schmidt et al.
Journal of chromatography. A, 1018(2), 155-167 (2003-11-19)
The overall topic of the investigation was the separation of basic proteins by cation exchange displacement chromatography. For this purpose two principal column morphologies were compared for the separation of ribonuclease A and alpha-chymotrypsinogen, two proteins found in the bovine
Nicoletta Potenza et al.
Nucleic acids research, 34(10), 2906-2913 (2006-06-02)
Human ribonuclease-1 (hRNase-1) is an extracellular enzyme found in exocrine pancreas, blood, milk, saliva, urine and seminal plasma, which has been implicated in digestion of dietary RNA and in antiviral host defense. The enzyme is characterized by a high catalytic
The preparation of subtilisn-modified ribonuclease and the separation of the peptide and protein components.
F M RICHARDS et al.
The Journal of biological chemistry, 234(6), 1459-1465 (1959-06-01)



Global Trade Item Number

SKUGTIN
R6000-100MG04061832759630
R6000-5MG04061832759647