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S0693

SB 204741

>98% (HPLC)

Synonym(s):

N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

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About This Item

Empirical Formula (Hill Notation):
C14H14N4OS
CAS Number:
152239-46-8
Molecular Weight:
286.35
NACRES:
NA.77
PubChem Substance ID:
24278321
UNSPSC Code:
12352200
MDL number:
MFCD00923644
Assay:
>98% (HPLC)
Form:
solid
Quality level:
100
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Quality Level

100

assay

>98% (HPLC)

form

solid

color

off-white to tan

solubility

DMSO: soluble >20 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChI key

USFUFHFQWXDVMH-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD5(1816), HTR1E(3354), HTR2A(3356), HTR2B(3357), HTR2C(3358)
rat ... Adra1a(29412), Gabra2(29706), Htr1a(24473), Htr2b(29581), Htr3a(79246)

Application

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
  • to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish
  • to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice
  • to test its effect in reducing scratching behavior evoked by sertraline in mice

Biochem/physiol Actions

5-HT2B serotonin receptor antagonist.
SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
013M4601V
108K46092
108K46091
108K4609
077K46143

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Ercan Ozdemir et al.
Bioelectromagnetics, 40(5), 319-330 (2019-06-04)
Much evidence demonstrates the antinociceptive effect of magnetic fields (MFs). However, the analgesic action mechanism of the electromagnetic field (EMF) is not exactly understood. The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor
Qiqi Yang et al.
Cellular and molecular gastroenterology and hepatology, 3(3), 484-499 (2017-05-04)
Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than in women. Although sex hormones are believed to play a critical role in this disparity, the possible contribution of other factors largely is unknown. We aimed to investigate the
Annika Gocht et al.
Transplant immunology, 49, 43-53 (2018-04-13)
Cardiac allograft vasculopathy (CAV) is the main obstacle for long-term survival after heart transplantation. Alloimmune mediated chronic vascular rejection results in several mechanisms like platelet activation, immigration of inflammatory cells through the endothelial layer and proliferation and migration of smooth
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Global Trade Item Number

SKUGTIN
S0693-50MG04061832084497
S0693-10MG04061836830595