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S106

SR-95531

≥98% (HPLC), GABAA receptor antagonist , powder

Synonym(s):

2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide, Gabazine

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About This Item

Empirical Formula (Hill Notation):
C15H18BrN3O3
CAS Number:
104104-50-9
Molecular Weight:
368.23
UNSPSC Code:
12352200
PubChem Substance ID:
24278819
NACRES:
NA.77
MDL number:
MFCD00055135
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Product Name

SR-95531, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

H2O: >10 mg/mL

SMILES string

[Br-].COc1ccc(cc1)-c2ccc(N)[n+](CCCC(O)=O)n2

InChI

1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChI key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
rat ... Gabra2(29706)

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
027M4603V
054M4601V
102M4606V
041M4624V
030M46181

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Marvin R Diaz et al.
PloS one, 8(1), e55673-e55673 (2013-02-06)
Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in CGNs (CGN-I(tonic))
Ian Duguid et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11132-11143 (2012-08-10)
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which
Le Chang et al.
Neuron, 77(3), 559-571 (2013-02-12)
Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis
View All Related Papers

Global Trade Item Number

SKUGTIN
S106-50MG04061836846367
S106-10MG04061836846350
SAB5200438-100UG04061832146386
SAB5200449-100UG04061832146492
SAB5200450-100UG04061832146508
SAB5200454-100UG04061832146546
SAB5200439-100UG04061832146393
SAB5200440-100UG04061832146409
SAB5200442-100UG04061832146423
SAB5200448-100UG04061832146485
SAB5200451-100UG04061832146515
SAB5200453-100UG04061832146539