S4441
D,L-Sulforaphane
≥90% (HPLC), liquid, phase II detoxification enzymes inducer
Synonym(s):
1-Isothiocyanato-4-(methylsulfinyl)-butane
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About This Item
Empirical Formula (Hill Notation):
C6H11NOS2
CAS Number:
Molecular Weight:
177.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
biological source
synthetic
Quality Level
assay
≥90% (HPLC)
form
liquid
solubility
DMSO: soluble 40 mg/mL, H2O: insoluble
compatibility
for use with ABI 7500
shipped in
dry ice
storage temp.
−20°C
SMILES string
CS(=O)CCCCN=C=S
InChI
1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChI key
SUVMJBTUFCVSAD-UHFFFAOYSA-N
Application
LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.
Biochem/physiol Actions
Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.
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Storage Class
10 - Combustible liquids
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Articles
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well as in vivo by causing apoptosis, but the sequence of events leading to cell
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S4441-5MG | 04061836926380 |