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S8809

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

Name: Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
Brand: SIGMA

~1 mg/mL, clone K58/35, purified immunoglobulin

Synonym(s):

Sodium Channel Antibody

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02097413

Conjugate:

unconjugated

Clone:

K58/35, monoclonal

Application:

IF, IHC (f), WB

Citations:

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Properties

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K58/35, monoclonal

species reactivity

mammals

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons, western blot: 1 μg/mL using crude brain membrane prep (rat)

isotype

IgG1

UniProt accession no.

P35498

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Description

General description

Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.

Immunogen

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na⁺ channels

Application

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:

immunohistochemistry(1:50)
immunostaining (1:200)
immunofluorescence
immunocytochemistry (1:100)

Biochem/physiol Actions

The sequence recognized by this clone is identical in all known vertebrate Na⁺ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.

Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.

Physical form

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

Legal Information

Sold under exclusive license from SUNY Stony Brook.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Regulatory Information

低风险生物材料

常规特殊物品

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Global Trade Item Number

SKU	GTIN
S8809-.1MG	04061836961084