SAB2702364
Monoclonal Anti-Iba1 antibody produced in mouse
clone GT10312, affinity isolated antibody
Synonym(s):
AIF-1, IBA1, IRT-1, IRT1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
GT10312, monoclonal
Application:
IF, IHC (p), WB
Citations:
14
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
GT10312, monoclonal
form
buffered aqueous solution
mol wt
17kDa
species reactivity
mouse, human, rat
concentration
2.03mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1000, indirect immunofluorescence: suitable, western blot: 500-3000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AIF1(199)
General description
Ionized calcium-binding adapter molecule 1 (IBA1), also called the allograft inflammatory factor 1 (AIF1) is mapped to human chromosome 6p21.33. It encodes a 17 kDa protein and comprises calcium binding EF hand motif. IBA1 is expressed in lung, tonsil, lymph node and spleen. In addition,it is also expressed in macrophages and glial cells.
Immunogen
Recombinant protein encompassing a sequence within the center region of human Iba1.
Application
Monoclonal Anti-Iba1 antibody produced in mouse has been used:
- in the double immunofluorescence
- in the immunofluorescence
- in immunohistochemistry
Biochem/physiol Actions
Ionized calcium-binding adapter molecule 1 (IBA1) interacts with filamentous actin (F‐actin) and L‐fimbrin. Its expression is modulated during injury. Inflammatory cytokines also induce IBA1 expression. IBA1 expression is implicated in the graft rejection in coronary artery vasculopathy (CAV). It is highly expressed in hepatocellular carcinoma and may serve a potential marker and therapeutic target. Increased expression of AIF1 in synovial fluid and peripheral blood monocytes is implicated in rheumatoid arthritis.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Phosphate-buffered saline, no preservative added.
Other Notes
Purification: Affinity purified by Protein G
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Expression of allograft inflammatory factor-1 in peripheral blood monocytes and synovial membranes in patients with rheumatoid arthritis
Pawlik A, et al.
Human immunology, 77(1), 131-136 (2016)
Expression of Allograft Inflammatory Factor-1 (AIF-1) in Hepatocellular Carcinoma
Zhang Q, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 6218-6218 (2018)
Xianliang Zhang et al.
Frontiers in aging neuroscience, 11, 78-78 (2019-04-27)
Recent studies have suggested that exercise may be beneficial for delaying or attenuating Alzheimer's disease (AD). However, the underlying mechanisms were not clear. Microglia-mediated neuroinflammation is suggested to play an important role in the pathology of AD. The present study
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB2702364-100UL | 04061837260032 |