Anti-AFP antibody produced in rabbit

The gene AFP (α fetoprotein) encodes a plasma glycoprotein that has a molar mass of 70kDa. The gene is mapped to human chromosome 4. The gene is evolutionarily-related to serum albumin, which is also mapped to human chromosome 4. It is synthesized along with serum albumin during the development of embryonic yolk sac and the liver.

AFP antibody was raised against a 14 amino acid peptide near the amino terminus of human AFP.

Anti-AFP antibody produced in rabbit has been used in immunoflorescence.

α-fetoprotein encoded by the gene AFP is involved in the regulation of fatty acids in both fetal and proliferating adult liver cells. Its expression is found to be increased in acute liver injuries, indicating active liver regeneration. It has been associated with fatty liver disease (FLD), a disease that may lead to cirrhosis and hepatocellular carcinoma. It serves as a tumor marker for HCC (hepatocellular carcinoma).

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Supplied in PBS with 0.02% sodium azide.

The action of this antibody can be blocked using blocking peptide SBP3500533.

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