SAB4200651
Monoclonal Anti-Histone H3 (C-terminal) antibody produced in mouse
clone H6.10, purified from hybridoma cell culture
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
H6.10, monoclonal
Species reactivity:
chicken, human, monkey, hamster, canine
Application:
IF
Citations:
14
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
H6.10, monoclonal
form
buffered aqueous solution
mol wt
antigen ~14 kDa
species reactivity
chicken, human, monkey, hamster, canine
concentration
~1 mg/mL
technique(s)
immunoblotting: 0.25-0.5 μg/mL using using histones isolated from human HeLa cells., immunofluorescence: 5-10 μg/mL using using HeLa cells.
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HIST1H3A(8350)
General description
Histone cluster 1 H3A (HIST1H3A) belongs to the H3 histone family. The gene encoding it is localized on human chromosome 6.
Monoclonal Anti-Histone H3 (C-terminal) (mouse IgG1 isotype) is derived from the hybridoma H6.10 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C terminal region of human Histone H3, conjugated to KLH.
Immunogen
a synthetic peptide corresponding to a sequence at the C terminal region of human Histone H3.
Application
Monoclonal Anti-Histone H3 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
Biochem/physiol Actions
H3.1 (Histone 3-variant 1) is involved in gene silencing as well as gene activation. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. Mutations in histone H3 were identified in various tumors.
Histone cluster 1 H3A (HIST1H3A) has been associated with DNA replication.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Related Content
Histone H3. 3 mutations: a variant path to cancer
Yuen B T K and Knoepfler P S
Cancer Cell, 24(5), 567-574 (2013)
FERONIA receptor kinase contributes to plant immunity by suppressing jasmonic acid signaling in Arabidopsis thaliana
Guo H, et al
Current Biology, 28(20), 3316-3324 (2018)
Organismal differences in post-translational modifications in histones H3 and H4
Garcia B, et al.
The Journal of Biological Chemistry, 282(10), 7641-7655 (2007)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4200651-100UL | 04061838037411 |